Product category:
Materials Testing
News Release from: Malvern Instruments | Subject: Zetasizer Nano particle characterisation system
Edited by the Manufacturingtalk Editorial
Team on 13 November 2006
Nano particle characterisation system
for drugs
Since its installation 18 months ago, a Malvern Zetasizer Nano particle characterisation system has proved indispensable at SoluBest.
Since its installation 18 months ago, a Malvern Zetasizer Nano particle characterisation system has proved indispensable at SoluBest, a drug delivery company based in Israel that uses advanced polymer formulations to prepare nanotransporters for drugs that are subject to delivery or compliance issues Solubest's Solumer Drug-Transport Nanotechnology is based on an innovative approach for designing therapeutic entities of the active drug molecule wrapped by regulatory approved polymers
This article was originally published on Manufacturingtalk on 26 Oct 2006 at 8.00am (UK)
Related stories
Nano particle characterisation system
At nano engineering company Sol-Gel Technologies (Bet Shemesh, Israel), Malvern's Zetasizer Nano particle characterisation system is proving to be an essential tool.
Nano particle characterisation system
A Malvern Zetasizer Nano particle characterisation system at Cornell University's NanoBioTechnology Center (NBTC) is being used for a wide variety of applications.
Many drug candidates are hydrophobic, and hence their bioavailability is poor, and the drug delivery mechanisms available are limited.
Selectively wrapping or coiling drugs in these polymers allows the materials to be solubilized with significantly increased surface area.
Dr Irene Jaffe, Director of Corporate Strategy at SoluBest explained: "Around half of all new drugs have associated delivery issues.
Further reading
Facilities for materials characterisation
A Malvern Zetasizer Nano particle characterisation system is one of a number of analytical solutions available to researchers at BegbrokeNano.
Control particle size, measurement and moisture
Two companies will be showing the latest developments in particle sizing systems for solids processing and infrared sensors for on-line measurement and control of moisture and composition.
We aim to provide better delivery systems for these and for existing compounds." The Zetasizer Nano is used in the characterization of the drug formulations to evaluate the nano particle entities produced, their size and the stability of the dispersions.
It is also used for characterizing the polymers themselves.
Here a variety of parameters, including concentration, pH, temperature and ionic strength, are examined to determine the optimum solution conditions, and are instrumental in the prediction of polymer structure and behaviour under different conditions.
One of the areas that has been particularly helpful to SoluBest has been the support the company has received from the Malvern team.
The unique character and properties of the polymer-drug entities involved in SoluBest's work has meant that assistance with applications and data interpretation has been a vital part of the package.
Malvern's Zetasizer Nano series simplifies the measurement of particle size, stability characterization using zeta potential, and molecular weight, for a wide range of dispersions, emulsions and molecules in solution.
It is the method of choice for nano-particle applications from routine colloid size measurements to the investigation of particulates at the leading edge of materials research.
Patented technologies ensure optimum performance for particle size measurement over the range 0.6 to 6000 nm, molecular weight measurement from 1 x 103 to 2 x 107 Daltons and the zeta potential of particles from 5 nm to 10 um. Request a free brochure from Malvern Instruments ...
• Malvern Instruments: contact details and other news
• Email this article to a colleague
• Register for the free Manufacturingtalk email newsletter
• Manufacturingtalk Home Page
Search the Pro-Talk network of sites
