Product category:
Materials Testing
News Release from: Malvern Instruments | Subject: Spraytec analysis tool for aerosolisation
Edited by the Manufacturingtalk Editorial
Team on 26 January 2007
Analysis of aerosolisation of inhalation
powders
At the recent Drug Delivery to the Lungs Conference Malvern Instruments presented the results of collaborative work on the aerosolisation of powders for inhalation.
At the recent Drug Delivery to the Lungs Conference (DDL 17, held 30th November - 1st December, Edinburgh, Scotland) Paul Kippax, product manager for diffraction systems at Malvern Instruments presented the results of collaborative work on the aerosolisation of powders for inhalation This work involved the use of the Malvern Spraytec particle size analyser to examine the time dependence of powder release from a dry powder inhaler (DPI)
This article was originally published on Manufacturingtalk on 9 Jan 2008 at 8.00am (UK)
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It was carried out in collaboration with Dr David Morton, a recognised expert in the development of inhalation systems.
The results demonstrate the value of the Malvern Spraytec as a screening tool for optimal inhaler design.
The interactions between a drug-containing powder formulation and an inhaler device are notoriously complex, and traditional techniques for their study have recognised limitations.
With the Spraytec system the time-dependence of the dose delivered can be measured rapidly for different formulations, providing reliable information for product optimisation.
In addition, the impact of various inhaler device characteristics can be assessed.
One conclusion from the work was that the Spraytec system provided improved insight into the mechanisms governing powder plume evolution.
It made possible the study of how the concentration of the plume changed over time during actuation, enabling a clearer understanding of the factors influencing the process of powder entrainment and dispersion.
It is expected that use of the Spraytec will accelerate product development and also the generation of successful formulations targeting specific areas of the respiratory system.
The Spraytec features an inhalation cell that is designed specifically for drug delivery applications.
It enables measurements to be carried out under fixed or varying flow conditions.
A data acquisition rate of 10 kHz coupled with a wide dynamic range allows the delivery profiles of both fine drug particles and coarser excipients to be captured simultaneously in exceptional detail. Request a free brochure from Malvern Instruments ...
Understanding the interactions between different components of a formulation is crucial to developing a product with the required dispersion characteristics.
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