Product category:
Materials Testing
News Release from: Metrohm UK | Subject: 718 STAT Titrino
Edited by the Manufacturingtalk Editorial
Team on 10 July 2003
pH Stat Titration in Synthesis
The pH stat method for tasks in synthesis and QC/QA enzyme characterization is proving more and more indispensable.
pH Stat Titration for tasks in synthesis and QC/QA enzyme characterization Whether pH or redox values have to be set or held makes no difference Per determination up to 500 data sets comprising volume, time and measured value are stored and processed to a typical pH stat curve, which can be printed out or displayed on your PC
This article was originally published on Manufacturingtalk on 24 Feb 2005 at 8.00am (UK)
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Per determination up to 500 data sets comprising volume, time and measured value are stored and processed with the 718 Stat Titrino to a typical pH stat curve, which can be printed or displayed.
Organic Synthesis At A Constant pH
In addition to measuring functions of pH, mV, Temperature, I Pol and Upol the 718 STAT Titrino also offers the following modes of analysis Stat, DOS, DOC and Tip.
The evaluation is performed by the 718 STAT Titrino.
Exothermic or endothermic synthesis is controlled by the 718 STAT Titrino: if the temperature gets outside the desired range the 718 will stop reagent addition, activate cooling or heating until the temperature is again within the set limits.
- The enzymatic methods of determination (e.g lipase, trypsin, antacids) used in pharmaceutical analysis, biology and medicine according to FIP (F?d?ration Internationale Pharmaceutique) are permanently stored along with other methods.
Further reading
Process chemicals can be analysed on-line
Metrohm has combined the best aspects of laboratory and online systems to produce the 875 ProcessLab: a fully customised, automated at-line system for analytical testing.
Determining water levels in lubricating oils
It is impoirtant to determine the presence of water in machinery lubricating oils, which is why Metrohm is offering its 831 KF Coulometer to give reliable results over a long period.
Metrohm electrodes - free storage DVD offered
Metrohm UK advised that companies ordering a new Metrohm electrode now will receive a free storage and maintenance DVD - offer expires on March 31, 2008.
The evaluation may take a relatively long time as both the intermediate results and the FIP standard determined between times are stored in a result silo.
This means greater statistical reliability.
The pH stat method is proving more and more indispensable in synthesis.
The compact 718 STAT Titrino offers solutions to demanding control tasks and investigations in the synthesis laboratory and pilot plant.
Modes: a.
STAT: pH stat with temperature monitoring b.
SET: titration to preselected endpoints c.
CAL: pH calibration d.
MEAS: measurement of pH/mV/C e.
DOC: pH/mV gradient controlled dosing with temperature monitoring It allows gradients of the measured value to be run.
If, for example, you wish to increase the pH value with NaOH from 4.0 to 8.0 within an hour, simply select the DOC mode and enter the two limit values using the keypad.
a.
DOS: dispensing of liquids with pH or temperature monitoring As a dispensing unit is integrated in the 718 STAT Titrino, complex dispensing tasks (DOS) using sensitive chemicals can be solved with safety features regarding temperature and pH monitoring.
a.
TIP: Linking of titration methods The TIP mode (Titration Procedure) of the 718 STAT Titrino can be used to link up to nine user methods, I/O commands or wait times to form a single method.
In addition to the stat functions, the 718 STAT Titrino offers measurement functions for pH, mV, T, Ipol and Upol, all of them functions for which you used to need special instruments and additional capital expenditure.
Typical applications STAT applications a.
Determination of enzyme activity (lipase, trypsin, etc) b.
Digestibility of fish meal c.
Kinetics of reactions with OH-, H+ or a redox component d.
pH stat titration of antacid tablets SET applications a.
Bromine number according to ASTM D 1159-84 b.
Chloride in water, foodstuffs and electroplating baths c.
Formol number in fruit juices d.
Hydrogen peroxide in various matrices e.
Kjeldahl nitrogen determination (conventional method with distillation) f.
Caustic and formaldehyde in an electroless copper bath g.
Sulphuric acid and zinc sulphate in Rayon spinning baths h.
Titratable acid in milk i.
Titratable acid in wine or fruit and vegetable juices j.
Vinegar in mayonnaise or ketchup k.
Water hardness (p and m values) in water samples.
Applications in the synthesis laboratory During the synthesis of chemical compounds, the characteristics of the starting materials as well as the experimental parameters - such as temperature, pH and the way in which reagents are added - play a decisive role in determining the course of the reaction.
Here are some examples for the use of the 718 STAT Titrino in the synthesis laboratory: a.
pH value, redox voltage or temperature measurement.
b.
Addition of a pre-determined reagent volume at a defined rate (mL/min) and free from pulsations.
c.
Set pH value, for example when neutralizing an amine or dissolving a substance.
d.
Continuous neutralization of an acid or a base that is split off in the course of a reaction.
The conversion rate can be determined from the amount of neutralization reagent consumed. Request a free brochure from Metrohm UK ...
pH Stat Titration.
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