Dynamic light scattering and screening

Wyatt Technology, a leader in absolute macromolecular characterization instrumentation and software has launched the DynaPro product range.

Wyatt Technology, the world leader in absolute macromolecular characterization instrumentation and software has launched the DynaPro product range.

Acquired during Wyatt's acquisition of Proterion/Protein Solutions Corporation in November 2004, the DynaPro Dynamic Light Scattering (DLS) system is the industry standard in the protein crystallization market.

The products are Wyatt Technology's first integrated solution for batch Dynamic Light Scattering and are its primary offering in the important field of high throughput screening.

Traditionally, Wyatt has dominated the Multi-Angle Light Scattering (MALS) market with its DAWN detectors; by incorporating the DynaPro range, Wyatt now offers its customers the complete light scattering solution.

The new DynaPro product line allows customers powerful yet easy-to-use tools for characterizing unfractionated samples via DLS.

The products particularly appeal to customers doing rapid characterization of size and polydispersity.

The range incorporates the automated DynaPro Titan Plate Reader, making the technology available for the rapid screening of unfractionated samples for applications such as crystallography and aggregation studies.

The product range offers the highest sensitivity and lowest sample volumes for protein crystallization by DLS.

It comes with a unique range of features including a control module with the ability to collect and analyze data; and a read module, which comes as either a temperature-controlled scintillation vial reader for single measurements, or a fully automated plate reader with the capability to make measurements on 96 or 384 well plates.

Other features include a stand-alone self-dessicating temperature chamber for low temperature conditions, and the ability to integrate seamlessly with Wyatt Technology's online accessories.

The DynaPro comes with easy-to-use software which will be integrated into Wyatt's 21 CFR 11-compliant ASTRA platform.

The software complements Wyatt's multi-angle light scattering detectors to make absolute molecular weight determinations a desirable alternative to traditional liquid chromatography methods.

"The DynaPro complements the Quasi-Elastic-Light Scattering instrument - WyattQELS - which is tuned for online analysis of fractionated samples, as it is ideal for batch analysis of unfractionated samples," comments Geof Wyatt, President of Wyatt Technology.

"Thus the addition of the DynaPro products positions Wyatt Technology as the leader in light scattering characterization for both online and batch analysis, plus the DynaPro Titan Plate Reader opens up the possibility of coupling light scattering characterization with automated robotic systems.

Wyatt now offers the whole range of light scattering solutions, including multi-angle light scattering, DLS and high throughput screening." The DynaPro DLS products are used globally in pharmaceutical, biotechnology, university and government-funded R and D laboratories, to understand the physical attributes of purified protein molecules.

The products make it much easier to characterize protein homogeneity.

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